Investigating the Invitro Pro-inflammatory Effects of Astrocyte-Derived Exosomes from Patients with a 历史 of COVID-19 和 Mild Traumatic Brain Injury.

Traumatic Brain Injuries (TBIs) 和 COVID-19 infections are both linked to heightened inflammatory responses within the central nervous system, which leads to cell death, increased release of pro-inflammatory cytokines, deregulation of the blood-brain barrier (BBB), 和 other harmful effects. The compounded impacts of inflammation phenotypes from COVID-19 和 mild TBIs have not been previously researched. Covid 和 TBI have both been found to lead to similar immune responses that increase inflammation in the brain by inflammatory pathways potentially mediated through exosomes. This study will evaluate if a history of TBI 和 COVID-19 infection in a patient’s isolated exosomes from astrocytes induces higher inflammation responses in cultured-rat-astrocytes, compared to a patient with either TBI history only, COVID-19 infection only, 或者是健康对照. Significantly increased cellular area 和 fluorescence from COVID-19 和 m TBI group demonstrate heightened inflammation phenotype compared to any other group. Currently, data is still being quantified, however, the qualitative analyses support these claims. Implications of this novel research establish a mechanism for neuroinflammation increase which can be used for pharmaceuticals 和 therapies targeting inflammation reduction.